Influence of High-Intensity Focused Ultrasound (HIFU) Ablation on Arteries: Ex Vivo Studies

High-intensity focused ultrasound (HIFU) has been used to ablate solid tumors and cancers. Because of the hypervascular structure tumor circulating blood inside it, interaction between HIFU burst vessel is a critical issue in clinical environment. Influences on lesion production potential rupture were investigated this study for efficiency safety ablation. An extracted porcine artery was embedded transparent polyacrylamide gel phantom, with bovine serum albumin (BSA) as an indicator thermal lesion, degassed water driven through sample. The focus aligned anterior wall, middle artery, posterior wall. After ablation, produced photographically recorded, then its size quantified compared that phantom without artery. In addition, bubble dynamics (i.e., generation, expansion, motion, shrinkage bubbles their artery) captured using high-speed imaging. It found presence resulted decrease both axial lateral directions. characteristics are dependent alignment. Acoustic hydrodynamic cavitation play important roles Both mechanical effects surface wall after However, no ex vivo study.